Passage times for polymer translocation pulled through a narrow pore.

نویسندگان

  • Debabrata Panja
  • Gerard T Barkema
چکیده

We study the passage times of a translocating polymer of length N in three dimensions, while it is pulled through a narrow pore with a constant force F applied to one end of the polymer. At small to moderate forces, satisfying the condition FN(nu)/k(B)T less, similar 1, where nu approximately 0.588 is the Flory exponent for the polymer, we find that tau(N), the mean time the polymer takes to leave the pore, scales as N(2+nu) independent of F, in agreement with our earlier result for F = 0. At strong forces, i.e., for, FN(nu)/k(B)T >> 1, the behavior of the passage time crosses over to tau(N) approximately N(2)/F. We show here that these behaviors stem from the polymer dynamics at the immediate vicinity of the pore-in particular, the memory effects in the polymer chain tension imbalance across the pore.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Passage times for unbiased polymer translocation through a narrow pore.

We study the translocation process of a polymer in the absence of external fields for various pore diameters b and membrane thickness L. The polymer performs Rouse and reptation dynamics. The mean translocation time (tau(t)) that the polymer needs to escape from a cell and the mean dwell time (tau(d)) that the polymer spends in the pore during the translocation process obey scaling relations in...

متن کامل

Probability distributions for polymer translocation.

We study the passage (translocation) of a self-avoiding polymer through a membrane pore in two dimensions. In particular, we numerically measure the probability distribution Q(T) of the translocation time T, and the distribution P(s,t) of the translocation coordinate s at various times t. When scaled with the mean translocation time T , Q(T) becomes independent of polymer length, and decays exp...

متن کامل

First passage time distribution of chaperone driven polymer translocation through a nanopore: homopolymer and heteropolymer cases.

Combining the advection-diffusion equation approach with Monte Carlo simulations we study chaperone driven polymer translocation of a stiff polymer through a nanopore. We demonstrate that the probability density function of first passage times across the pore depends solely on the Péclet number, a dimensionless parameter comparing drift strength and diffusivity. Moreover it is shown that the ch...

متن کامل

Anomalous dynamics of unbiased polymer translocation through a narrow pore

We consider a polymer of length N translocating through a narrow pore in the absence of external fields. The characterization of its purportedly anomalous dynamics has so far remained incomplete. We show that the polymer dynamics is anomalous up to the Rouse time τR ∼ N1+2ν , with a mean square displacement through the pore consistent with t (1+ν)/(1+2ν), with ν ≈ 0.588 the Flory exponent. This...

متن کامل

Coarse-grained simulation of polymer translocation through an artificial nanopore

The translocation of a macromolecule through a nanometer-sized pore is an interesting process with important applications in the development of biosensors for single–molecule analysis and in drug delivery and gene therapy. We have carried out a molecular dynamics simulation study of electrophoretic translocation of a charged polymer through an artificial nanopore to explore the feasibility of s...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Biophysical journal

دوره 94 5  شماره 

صفحات  -

تاریخ انتشار 2008